Alternative to the diffusion equation in population genetics

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Alternative to the diffusion equation in population genetics.

Since its inception by Kimura in 1955 [M. Kimura, Proc. Natl. Acad. Sci. U.S.A. 41, 144 (1955)], the diffusion equation has become a standard technique of population genetics. The diffusion equation is however only an approximation, valid in the limit of large populations and small selection. Moreover, useful quantities such as the fixation probabilities are not easily extracted from it and nee...

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Singular solutions of the diffusion equation of population genetics.

The forward diffusion equation for gene frequency dynamics is solved subject to the condition that the total probability is conserved at all times. This can lead to solutions developing singular spikes (Dirac delta functions) at the gene frequencies 0 and 1. When such spikes appear in solutions they signal gene loss or gene fixation, with the "weight" associated with the spikes corresponding to...

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Population Genetics: Difference Equation Models

The diversity of life is a fundamental empirical fact of nature. Casual observation alone confirms the great variety of species. But diversity also prevails within single species. As in human populations, the individuals of a species vary considerably in their outward traits—size and shape, external markings, fecundity, disease resistance, etc. This is called phenotypic variation, and, since ph...

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Singular solutions of the di¤usion equation of population genetics

The forward di¤usion equation for gene frequency dynamics is solved subject to the condition that the total probability is conserved at all times. This can lead to solutions developing singular spikes (Dirac delta functions) at the gene frequencies 0 and 1. When such spikes appear in solutions they signal gene loss or gene …xation, with the “weight”associated with the spikes corresponding to th...

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ژورنال

عنوان ژورنال: Physical Review E

سال: 2010

ISSN: 1539-3755,1550-2376

DOI: 10.1103/physreve.82.051913